In the current era of technological advancements, artificial intelligence (AI) stands out as a transformative force impacting health, education, public policies, and sustainability. "AI and the SDGs in Latin America and the Caribbean" explores how AI can be crucial for sustainable development, showcasing case studies and its strategic application in key sectors to address urgent challenges.This work highlights the opportunities and ethical challenges of AI. The collaboration between CAF and Microsoft drives digital transformation in the region to enhance quality of life, promote efficient and innovative governance, and tackle the challenges and opportunities of the digital age.